As a novel transdermal drug delivery system,dissolvable microneedle has broken the limitations of traditional transdermal formulations which are not able to deliver macromolecular.Besides the aspect of macromolecular delivery,dissolvable microneedles have numerous advantages including small enough to avoid causing pain,minimal skin trauma,no bleeding or introduction of pathogens,good biocompatibility,easy to self-administration,etc.The study of dissolvable microneedle has recently become a hot topic.The choice of matrix materials directly affects the preparation process of microneedle,as well as the properties of skin puncturing and drug releasing.This paper introduces the research status of dissolvable microneedle,classifies and introduces the matrix materials,then summarizes the use of their compounds.The properties of ductile materials and brittle materials and their synergistic effects after composite are introduced as well.Finally,the existing problems and research directions in this field are discussed.%可溶性微针作为新型透皮给药制剂,打破了传统皮肤给药制剂不能用于大分子药物经皮给药的局限,且具有无痛、无创、无出血、卫生、生物相容性好、便于患者自主使用等诸多优点.近年来可溶性微针的研究已成为备受关注的热点.基质材料的选择直接影响微针的制备及皮肤刺入、药物释放等性能.介绍了可溶性微针的研究现状,对基质材料进行了分类与介绍,并综述了基质材料的复合使用及效果.同时介绍了韧性材料和脆性材料的特性及其复合后的协同效果,进而对该领域存在的问题和研究方向进行了讨论和展望.
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