The research status of the biological nanometer holes and the solid nanopore are reviewed. The α-HL hemolysin hole, preparation of biological nanopores and artificial solid-state nanopore sensor as well as detecting of single molecule and determination of the DNA sequencing are focused on. The development trends and application prospect are discussed too.%综述了单纳米孔传感器中的生物纳米孔和固态纳米孔的研究现状,重点介绍了α-HL溶血素孔、生物纳米孔及人工固态纳米孔传感器的制备,以及单纳米孔传感器在单分子检测和DNA测序方面的应用进展,并展望了该领域的发展趋势和应用前景.
展开▼
