Objective: To observe the clinical ef ect of dezocine combined with propofol in painless gastroscopy, safety and quality of recovery. Methods: 200 patients undergoing gastroscopy patients, were randomly divided into A, B two groups of 100 cases. A group of dezocine combined with propofol group; group B propofol group. Patients in group A intravenous dezocine 40ug/kg, then slow intravenous injection of propofol 1.5mg/kg (4ml/10s); B group at the same speed of intravenous injection of propofol alone, according to the depth of sedation of propofol, to sleep, to knock the eyebrow no reaction or deep sleep or loss of consciousness, in anesthesia, total y inhibited pharyngeal reflex. Record the ef ect, dosage of propofol anesthesia in two groups of patients, recovery time, leave hospital time, adverse reaction. Results:the two groups of patients with anesthesia ef ect in A group was higher than that of group B (p<0.05). The time to leave the hospital, the adverse reaction of A, B group had no significant dif erence. (P>0.05). Recovery of consciousness, the dosage of propofol A, there was significant dif erence in B group (P<0.05). Conclusion:dezocine combined with propofol for painless gastroscopy is safe and ef ective, good analgesic ef ect, the dosage of propofol significantly reduce, not increase the adverse reaction.%目的：观察地佐辛复合丙泊酚在无痛胃镜检查中的临床效果、安全性与苏醒质量。方法选择200例行胃镜检查的患者，随机分为A、B两组每组100例。A组为地佐辛复合丙泊酚组；B组为单纯丙泊酚组。A组患者静脉注射地佐辛40ug/kg，然后缓慢静注丙泊酚1.5mg/kg（4ml/10s）；B组按同样速度单纯静注丙泊酚,据镇静深度追加丙泊酚，直至入睡、对叩眉无反应或深睡或意识消失、处于麻醉状态，完全能抑制咽喉反射。记录两组患者麻醉效果，丙泊酚用量，苏醒时间，离院时间，不良反应。结果两组患者麻醉效果A组明显优于B组（P<0.05）。离院时间、不良反应A、B组无显著差异（P>0.05）。意识恢复、丙泊酚用量A、B组有显著差异（P<0.05）。结论地佐辛复合丙泊酚用于无痛胃镜安全有效、镇痛效果良好，丙泊酚用量明显减少，并不增加其不良反应。
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