Objective To explore the ef ect of celecoxib for induction of multimodal analgesia. Methods Choose 120 pregnant need to terminate pregnancy patients, randomly divided into three groups,each group of 40 cases. Epidural analgesia group (A),intravenous analgesia group (B),oral administration of celecoxib combined with fentanyl analgesia group (C),does not require analgesia in 40 cases of pregnant women as the control group (D). The analgesic ef ect of analgesia was recording,and record the mean arterial blood pressure,heart rate,respiration,pulse oximetry,record adverse reactions,each group of pregnant women. Results Compared with A group,C group, <0.01) significantly faster onset time. Each time VAS scores,A,B,C three group less than those in D group ( <0.01),no significant A,B,C in the three groups between group dif erences ( >0.05). Compared with B group,the incidence of nausea and vomiting in group C was significantly less ( <0.01). Compared with A group,lower limb numbness occurred rate of group C was significantly less ( <0.01). Compared with A,B two group,the total incidence of adverse reaction in group C was significantly lower ( <0.01). Conclusion Intravenous analgesia,reliable ef ect,but the ef ect is poor in epidural analgesia. Celecoxib oral y,combined with intravenous analgesia for labor analgesia,the analgesic ef ect of epidural analgesia,can achieve convenient operation,no damage,is a safe,comfortable,reliable analgesia.%目的探讨塞来昔布联合芬太尼静脉自控镇痛在引产中的效果。方法选120例孕中期需终止妊娠患者，随机分三组，每组40例，分别为单纯硬膜外镇痛组（A）、单纯静脉镇痛组（B）和口服塞来昔布联合芬太尼静脉镇痛组（C），另随机选择同期未要求镇痛的孕妇40例作为对照组（D）。记录各组孕妇的镇痛起效时间，镇痛效果，记录平均动脉压、心率、呼吸、脉搏血氧饱和度，记录不良反应。结果与A组相比，C组起效时间明显较快(<0.01)，A、B、C三组各时点VAS评分均明显小于D组(<0.01)，A、B、C三组组内组间差异无统计学意义（跃0.05）。与B组相比，C组恶心呕吐发生率明显较少(<0.01)，与A组相比，C组下肢麻木发生率明显较少(<0.01)，与A、B两组相比，C组总不良反应发生率明显较小(<0.01)。结论静脉镇痛起效快、效果可靠，但其镇痛效果略逊于硬膜外镇痛。塞来昔布口服，加静脉镇痛用于引产镇痛，可以达到硬膜外镇痛的镇痛效果，操作方便，无损伤，是一种安全舒适、可靠的镇痛方式。
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