目的研究右美托咪定复合丙泊酚全麻诱导对麻醉深度,血流动力学及丙泊酚用量的影响。方法 ASAⅠ~Ⅱ级择期行腹腔镜下胆囊切除术患者40例，年龄18~60岁，体重50~80kg。随机分为两组，每组20例。 D组右美托咪定1μg/kg10min内泵注完毕，N组给予同等容量生理盐水，随后两组推注丙泊酚待BIS值降到60后给3μg/kg芬太尼，0.2mg/kg顺式阿曲库铵，2.5min后插管。观察入室T0，诱导后5minT1，10minT2插管即刻T3，插管后1minT4，2minT5的心率，收缩压，舒张压和BIS值。结果 D组丙泊酚用量明显少于N组，D组在T1 T2时BIS值显著低于N组，N组在T3 T4收缩压，舒张压明显低于D组，D组心率在T2时明显低于N组。结论1μg/kg右美托咪定全麻诱导可明显降低BIS值减少丙泊酚用量，血流动力学更稳定。%Objective To investigate the change of bispectral,hemodynamic and the dose of propofol after the usage of Dexmedetomidine in the induction of general anesthesia.Methods Forty patients ,graded ASAⅠ~IIdegree,undergoing gal bladder resection ,were randomized to placebo (groupN) or Dexmedetomidine (groupD) group. Dexmedetomidine1μg/kg or the same volume of saline were intravenous injected in 10 minutes,respectively.Then the two groups induced with propofol,when BIS reduced to 60 we give them fentanly 3μg/kg and cis-atracurium 0.2μg/kg,2.5 minutes later we operated tracheal intubation.BIS,HR,SBP,DBP were recorded intervals before induction,5 minutes and 10 minutes after induction,tracheal intubation,1 minute,2 minute after tracheal intubation and we also recorded the dosage of propofol.Results There was no significant dif erence between the two group before anesthesia induction.The dosage of propofol in group D was significant fewer than group N.BIS of group D was lower than group N at time T1 and T2.Compared with group D,SBP and DBP of group N decreased significant at time T3 and T4.HR of group D decreased significant than that of group N at time T2.Conclusion Dexmedetomidine 1μg/kg can significant reduce the value of BIS and the dosage of propofol when used it in general anesthesia induction.The hemodynamic is more stable than used propofol alone.
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