In recent years, the incidence of hepatocellular carcinoma has gradually increased, and it has become a worldwide health concern, and patients often have a late diagnosis, an opportunity to lose surgery, and a poor prognosis. At present, targeted therapy and immunotherapy are another milestone after traditional chemoradiotherapy. They are widely used in the treatment of advanced liver cancer. Many drugs have been proven to have clear survival benefits and good safety. Hepatocellular carcinoma is reviewed in the field of targeted therapy and immunotherapy.%近年来, 肝细胞肝癌的发病率呈逐渐上升趋势, 已成为世界范围关注的健康问题, 且患者常常初诊已为晚期, 失去手术治疗的机会, 预后较差.目前靶向治疗和免疫治疗是继传统放化疗之后的又一里程碑式进展, 其在晚期肝癌治疗中应用广泛, 多种药物已被证实有明确的生存获益及良好的安全性, 本文主要就肝细胞肝癌在靶向治疗和免疫治疗方面的研究情况进行综述.
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