目的 观察脑外伤合并四肢长管状骨骨折患者不同时间段血清瘦素浓度变化.方法 连续选择21例脑外伤合并四肢长管状骨骨折患者(观察组)和26例单纯四肢长管状骨骨折患者(对照组),入选对象均在骨折后第1、3、7、14天接受了血清瘦素浓度测定,同时统计下床活动时间、骨折愈合时间和住院总时间等疗效指标.结果 两组患者骨折后第1天时检测血清瘦素浓度无明显区别(P＞0.05);而第3、7、14天,观察组血清瘦素浓度均明显高于对照组(P均<0.05).观察组的骨折愈合时间明显短于对照组,而前者住院总时间明显多于对照组(P均<0.05).结论 脑外伤合并四肢长管状骨骨折患者病后第3、7、14天时间段血清瘦素浓度明显升高,骨折愈合时间较短.%objective To study the changes in the concentrations of serum leptin at different phases in patients with brain injury accompanied by long tubular bone fracture in limbs. Methods Twenty - one patients with brain injury accompanied by long tubular bone fracture in limbs (observed group) and 26 patients with simple long tubular bone fracture in limbs control group were successively selected, and the concentrations of serum lepfin were determined in all the enrolled subjects at days 1, 3, 7 and 14 after hospitalization. Meanwhile, the curative indexes including time of off - bed activity, time of fracture healing and total length of hospitalization were observed. Results There was no significant difference in changes of serum leptin concentration at day I after hospitalization botween the observed group and the control group (P ＞0.05). The concentrations of serum ieptin at days 3, 7 and 14 after hospitalization in the observed group were significantly higher than those in the control group at the same periods ( P ＜ O. 05 ). The time of fracture healing in the observed group were significantly shorter than that in the control group, whereas the total length of hospitalization in the observed group was significantly longer than that in the control group (P < 0.05). Conclusions The concentrations of serum leptin at days 3, 7 and 14 after hospitalization are significantly increased and the time of fracture healing is shorter in patients with brain injury aceompaniod by long tubular bone fracture in limbs than that in patients with simple long tubular bone fracture in limbs.
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