Objective:To investigate effects of early enteral nutrition on inflammatory factor levels in patients with severe acute pancreatitis. Methods:80 cases of acute severe pancreatitis patients were randomly divided into observation group and control group according to the random number table, 40 cases in each group. The observation group and control group were treated with early enteral nutrition and early parenteral nutrition. 7d after the treatment,the levels of inflammatory factors and clinical symptoms were compared between the two groups. Results:The length of stay and hospitalization costs of the observation groupwere significantly lower than those of control group (P<0. 05). 3d and 7d after the treatment, the levels of tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), IL-6, IL-8, IL-10 and endotoxin of the observation groupwere significantly lower than those of control group (P<0. 05). Mo-reover, the APACHE-II score, intestinal function recovery time, SIRS improvement time, MODS rate, and pancreas and peripancreat-ic infection rate of the observation groupwere significantly lower than those of control group (P<0. 05). Conclusions:Early enteral nu-trition can effectively reduce the levels of the inflammatory factors in the patients with severe pancreatitis.%目的：：观察早期肠内营养治疗对急性重症胰腺炎患者炎性因子水平的影响。方法：将80例急性重症胰腺炎患者按照随机数字表法分为观察组和对照组，每组各40例。对照组患者给予早期肠外营养治疗；观察组患者给予早期肠内营养治疗。治疗7 d后，比较两组患者的炎性因子水平和临床症状改善情况。结果：观察组患者的住院时间、住院费用均明显低于对照组(P<0.05)；治疗后第3、7天，观察组患者的肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、IL-6、IL-8、IL-10及内毒素水平均明显低于对照组(P<0.05)；观察组患者的A-PACHE-Ⅱ评分、肠功能恢复时间、SIRS改善时间、MODS发生率和胰腺及胰周感染率均明显低于对照组(P<0.05)。结论：早期肠内营养治疗较早期肠外营养治疗能有效降低重症胰腺炎患者体内炎性因子水平。
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