Objective:To study characteristics of cognitive dysfunction for patients with remitted depression and provide an evi-dence for the clinical intervention. Methods:Event-related potentials (P300), Wechsler memory scale (WMS) and Wisconsin card sorting test ( WCST) were employed to detect the cognitive function of 60 patients with remitted depression. Moreover, 60 health peo-ple with matched gender, age, and education were selected as controls. Results:The latency period of P300 in the patients with remit-ted depression was longer and the amplitude of P300 was smaller than those in the controls. There were significant differences in six i-tems of WCST between the two groups (P<0. 01), wherein the number of error response, the necessary response number to complete the first category, persistent errors and non-persistent errors of the patients with remitted depression were all higher than those of the controls, however, the completed categories and conceptualization percentage were lower than those of the controls (P<0. 05). Fur-ther, in the WMS, except the immediate memory, other indicator scores ( long term memory, short term memory and memory quotient) were lower than those of the controls (P<0. 05). Conclusions:The patients with remitted depression still have cognitive impairment, especially memory and executive dysfunction.%目的：探讨缓解期抑郁症患者认知功能障碍的特点,为临床干预提供依据。方法：采用事件相关电位P300、韦氏记忆量表( WMS)和威斯康星卡片分类测验( WCST)对60例缓解期抑郁症患者进行认知功能评定,选用60例性别、年龄、受教育年限等均相匹配的健康对照。结果：缓解期抑郁症患者P300潜伏期延长,波幅降低；WCST六项主要指标与对照组均有显著差异,其中错误应答数、完成第一项分类所需应答数、持续性错误数及非持续错误数均高于对照组,而完成分类数项及概念化水平百分数(%)低于对照组(P<0.05)；此外,WMS测定中除瞬时记忆(背数)外,其他各项指标(长时记忆、短时记忆、记忆商)均较对照组分数低(P<0.05)。结论：缓解期抑郁症患者仍存在认知功能损害,特别是记忆和执行功能。
展开▼
