Objective:To investigate physiological and biochemical differences between residents of different altitudes in adap-tation to hypoxia, and analyze acclimatization phenomenon of plain migrants. Methods:The plateau native college students (n=40, as control group, male 20 and female 20), and plain college students (n=40, as experimental group, male 20 and female 20) were se-lected and analyzed the differences of hypoxia adaptation through some parameter indices. Further, the acclimatization phenomenon of the plain college student two years before and after the migration were analyzed and compared. Results: The red blood cell (RBC), he-moglobin (Hb), hematocrit (Hct), platelet (PLT), oxygen saturation (SaO2 ) of experimental group were significantly lower than those of control group (P<0. 05), while creatine kinase (CK) was significantly higher than that of control group(P<0. 05). Two years later, the plain students received a good acclimatization, and the RBC, Hb, Hct and SaO2 of the plain students in 2013 was signifi-cantly higher than those in 2011(P<0. 05), and CK was significantly lower than that in 2011 (P<0. 05). Conclusions: Two years lat-er, the plain students receive a good acclimatization.%目的：探讨不同海拔地区居民在低氧适应的生理与生化方面的差异，以及平原移居高原的习服现象。方法：选取高原世居大学生40名(男、女各20名)作为对照组，平原大学生40名(男、女各20名)作为实验组进行参数指标对比，分析两组大学生之间低氧适应的差异性；选取平原大学生移居两年前后对比分析平原移居大学生的习服现象。结果：初入高原的平原大学生的红细胞(RBC)、血红蛋白(Hb)、红细胞比容(Hct)、血小板(PLT)、血氧饱和度(SaO2)明显低于高原组(P<0.05)，心肌肌酸激酶(CK)明显高于高原组(P<0.05)；2013年组大学生的 RBC、Hb、Hct 和 SaO2明显高于2011年组(P<0.05)；CK 明显低于2011年组(P<0.05)。结论：两年后平原大学生获得了良好的习服。
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