目的：探讨延边地区朝鲜族和汉族男性TNF-α238基因型、等位基因频率及其与酒精性肝病的关系。方法：应用PCR-RFLP方法检测延边地区朝、汉族男性酒精性肝病患者(损伤组)和健康对照人群(对照组) TNF238基因多态性，计算和比较各组基因型和等位基因的频率。结果：朝鲜族男性酒精性肝损伤组患者和健康对照组人群的TNF-α238A等位基因出现的频率分别为：1.79%、1.0%，两者之间基因多态分布无显著性差异(P>0.05)。汉族男性酒精性肝损伤组患者和健康对照组人群的TNF-α238A等位基因出现的频率分别为：1.89%、1.11%，两者之间基因多态分布无显著性差异(P>0.05)。结论：延边地区朝鲜族和汉族男性酒精性肝损伤发生与TNF-α238基因多态性无显著相关性。%Objective:To investigate relationship between TNF-α 238 genotype, allele frequency and alcohol liver disease ( ALD) in Korean and Han men of Yanbian area in China. Methods:Polymerase chain reaction-restriction fragment length polymor-phism was used to detect TNF-α238A gene single nucleotide polymorphism in ALD group and health control group in Korean and Han men of Yanbian area. We calculated and compared the genotype and allele frequencies in each group. Results:In Korean men, the al-lele frequencies of TNF-α238 were 1. 79% and 1. 0% in the ALD group and health control group, and there was no significant differ-ence of TNF-α238A gene polymorphism distribution between the two groups (P>0. 05). In Han men, the allele frequencies of TNF-α238 were 1. 89% and 1. 11% in the ALD group and health Control group, and there was no significant difference of TNF-α238A gene polymorphism distribution between the two groups. Conclusions:There is no significant relationship between TNF-α238 polymor-phism and ALD in Korean and Han men of Yanbian area.
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