Objective:To study the epidemiology and clinical characteristics of cases of severe hand-foot-mouth disease ( HFMD) in Nanyang city, and to provide a basis for prevention and treatment of the disease. Methods:112 hospitalized cases with se-vere cases were analyzed by epidemiological and clinical characteristics. Results:The onset age was more concentrated in the age of be-low 4 (90. 2%), more boy than girl. The high prevalence was in May-July. The incidence of rash and fever were both 100%;the in-cidence of central nervous system lesions was 92. 0%; the incidence of digestive symptoms was 31. 3%; the incidence of respiratory symptoms was 43. 8%;and the incidence of circulatory system symptoms was 60. 7%. EV-71 infection rate (83. 4%) was signifi-cantly higher than A16 infection rate (9. 8%) (P<0. 01) by etiology checking. Conclusions:In the severe cases of HFMD, EV-71 infection rate is in a serious condition;it is mainly for central nervous system lesions. Early forecasting and identifying severe cases, and taking timely and effective interventions to block the progress of the disease can significantly reduce the incidence of severe cases, and lower the death rate of sick children.%目的：研究南阳市手足口病重症病例患儿流行病学及临床特征,为防治该病提供依据。方法：对收治的112例住院重症病例进行流行病学及临床特征分析。结果：发病年龄多集中在4岁以下(90.2%),男性多于女性,5~7月发病率较高,皮疹和发热发生率均为100%,中枢神经系统病变发生率为92.0%,消化系统症状发生率为31.3%,呼吸系统症状发生率为43.8%,循环系统症状发生率为60.7%。病原学检查EV-71感染率(83.4%)显著高于A16感染率(9.8%)(P<0.01)。结论：手足口重症病例中,以EV-71感染率高病情严重,主要表现为中枢神经系统病变。早期预测及识别重症病例,及时采取有效干预措施阻断病情进展,可显著降低危重病例发生率,降低患儿死亡概率。
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机译：Convegno。我在eta pediatrica gemelli：流行病学，临床心理学。 Istituto superiore di sanita。罗马，2009年11月16日。（国会。童年时期的双胞胎：流行病学，临床和心理方面.Istituto superiore di sanita。罗马，2009年11月16日。会议录）
