阻塞性睡眠呼吸暂停综合征(OSAS)会导致慢性睡眠分裂及间歇性低氧血症,进而引起认知功能障碍,特别是注意力、执行功能、记忆等方面.其导致患者认知功能障碍的机制主要包括睡眠结构改变、间歇性缺氧、分子生物学改变.而不同的治疗方案对OSAS患者认知功能障碍的改善情况不尽相同,其中持续气道正压通气在认知功能障碍方面的改善较其他方案有明显优势,患者认知功能可得到部分逆转,但结果并不完全令人满意.目前,OSAS所致认知功能障碍的分子机制尚不明确,进一步进行分子生物学研究有助于明确病因,从而发现新的治疗方案对临床早期干预具有重大意义.%Obstructive sleep apnea syndrome ( OSAS) can lead to chronic sleep fragmentation and intermittent hypox-emia,and cause the cognitive impairment ,especially in attention ,executive function and memory .The mechanisms of OSAS patients with cognitive dysfunction mainly include:sleep structure changes,intermittent hypoxia,molecular biological chan-ges.The improving effect of different treatments on cognitive dysfunction in OSAS patients is not the same ,and the continu-ous positive airway pressure on cognitive dysfunction has obvious advantage ,which may realize partial reversal of the cogni-tive function,though the result is still not entirely satisfactory .At present,the molecular mechanism of cognitive dysfunction induced by OSAS is not clear .Further research on molecular biology is helpful to identify the mechanism ,and it will be of great significance to the early clinical intervention .
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