As a phosphatidylinositol kinase (PI3K) 3-family member,phosphatidylinositol 3-kinase reg-ulatory subunit 2 (PIK3R2),through the phosphatidyl inositol 3 kinase/protein kinase B (PI3K/AKT) sig-naling pathway involved in the regulation of the formation,maintenance,and remodeling of the vasculature,is an important gene regulation target of the normal development,tissue response to injury,and tumor progres-sion.In different tumors,there are differences of miRNA-126-mediated PIK3R2 regulatory levels and trends, which may be associated with tumor progression.Therefore,PIK3R2 may be one of the promising target genes for the tumor studies.%磷脂酰肌醇3-激酶调节亚基2（PIK3R2）是磷脂酰肌醇3-激酶（PI3K）的家庭成员之一，通过PI3K／蛋白激酶B（Akt）信号通路参与血管的形成、维护以及改造的调控，是组织器官正常发育、损伤以及肿瘤发生的一个重要的基因调控靶目标。不同类型的肿瘤，微RNA（miRNA）126介导的PIK3R2调控水平及趋势存在差异，可能与肿瘤的发生存在联系，是肿瘤研究中有前景的调控靶目标之一。
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