微RNA（ miRNA）是一类长约22个核苷酸的内源性非蛋白质编码的小分子 RNA，它通过对目标mRNA的剪切和翻译抑制，发挥对基因表达的转录后调控作用。 miRNA具有多靶点的特性，至少参与约1／3人类蛋白质的表达调控，并且参与调控细胞分化、凋亡，肿瘤形成、免疫反应等多种生物学行为。近些年研究表明，miRNA对于调控非酒精性脂肪性肝病的基因表达、调节脂质形成和储存至关重要。%MicroRNA( miRNA) is a class of 22 nucleotides endogenous non-protein-coding small mole-cule RNA,which regulates gene expression after transcription through splicing and translation of the target mRNA inhibition.miRNA has multiple targets,and is involved in the expression regulation of at least about 1/3 human protein,and participates in biological behaviors including the regulation of cell differentiation , apoptosis,tumor formation,and immune response.In recent years,research shows that miRNA is essential to the regulation of gene expression of nonalcoholic fatty liver disease, lipid formation and storage.
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