肾素-血管紧张素-醛固酮系统(RAAS)是一种调节血压及血容量的关键系统.RAAS的过度激活会导致高血压相关的器官损害.肾素抑制剂作用于RAAS的第一限速步骤,抑制该步骤能够提供良好的血压控制及器官保护作用.阿利吉仑是一类新的直接肾素抑制剂,在普通高血压患者中阿利吉仑能够有效地降低血压.同时,阿利吉仑对心脏、肾脏的保护作用被大量临床研究证实.阿利吉仑在老年、肥胖、糖尿病等特殊高血压人群中亦有不错的的降压效果.%The reninangiotensin-aldosterone system( RAAS )is a key mediator of blood pressure( BP )and volume regulation. Over-stimulation of HAAS also contributes to hypertension-related target organ damages. Renin inhibitor interferes with the first rate-limiting step in RAAS, the inhibition of which is a very attractive target for lowering blood pressure and target-organ protection. Aliskiren,a direct renin inhibitor, is the first example of a novel class of antihypertensive drugs with potent antiproteinuric effects. Meanwhile, the protection on the heart and kidney of aliskiren has been proved by a large number of clinical trials. Aliskiren also has a good pressure reduction on the special patient group such as the elderly,obesity and diabetes.
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