类风湿性关节炎(RA)是一种不明原因的多系统性自身免疫性疾病,以关节滑膜炎、血管翳及对称性、破坏性的关节病变为主要特征.肿瘤坏死因子α(TNF-α)是RA病程中最早产生的细胞因子之一,可与其他细胞因子一起具有促进RA滑膜血管新生.TNF-α介导的核因子κB信号通路在RA炎性反应、血管形成中发挥重要作用,研究此信号通路对RA有重要意义.%Rheumatoid arthritis( RA )is a kind of autoimmune disease of unclear causes with multiple systems involved mainly characterized by synovial inflammation, pannus and symmetrical, destructive arthritis. Tumor necrosis factor alpha( TNF-α )is one of the earliest cytokines in RA pathogenesis, which together with other cytokines has the RA synovial angiogenesis promotion function. TNF-αunduced NF-κB pathway plays an important role in RA inflammatory response and angiogenesis, thus studying the signal pathway is of great significance to RA.
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