柴胡皂苷是中药柴胡中具有生物活性的一类三萜皂苷,具有解热、镇痛、镇静、抗炎、保肝、止咳、抗病毒、抗溃疡等多种药理活性.现对近年来国内外有关柴胡皂苷吸收与代谢方面的研究进展,包括其胃肠道转化、肠吸收和药动学性质等进行综述,这将有助于了解柴胡皂苷类物质的体内过程,以期为进一步研究提供思路.%Saikosaponins are a class of triterpene saponins with a wide spectrum of bioactivities such as antipyretic, analgesic, sedative, anti-inflammatory, hepatoprotective, anti-cough, anti-virus, anti-ulcer and other pharmacological activities. Here is to make a review on recent research progress of saikosaponin absorption and metabolic in and out of China,including the biotransformation in gastrointestinal tract,intestinal absorption and pharmacokinetic properties,etc. with the hope that it would be a help to claim the in vivo action of saikosaponins and to provide ideas for further studies.
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