Objective To evaluate the clinical significance of the changes of Brain natriuretic peptide ( BNP )levels in patients with chronic heart failure( CHF ). Methods 60 consecutive patients hospitalized for CHF were retrospectively studied. BNP and left ventricular end-diastolic dimension( LVEDD ), left ventricular ejection fraction( LVEF )were measured and compared in 60 patients of the observation group and 60 of the control group. Results The plasma BNP levels of patients in the observation group were significantly higher than controls( P <0.05 ). The plasma BNP level in patients with cardiac function NYHA Ⅰ , Ⅱ ,Ⅲ, IV were significantly higher than controls in ascending order. BNP,LVED levels lowered in patients of different degrees of cardiac function disease after treatment P <0.05 ),while LVEF was significantly higher than before the treatment, which was of statistical significance( P <0.05 ). Conclusion The blood plasma BNP level may be used in the early diagnosis of heart failure and the prognosis evaluation, and has good value for diagnosis of diastolic dysfunction.%目的 分析慢性心力衰竭患者脑钠肽(BNP)水平变化的临床意义.方法 选择慢性心力衰竭患者60例作为观察组,按照1∶1的比例选择同期心内科非心力衰竭患者60例作为对照组,观察不同程度心力衰竭患者左心室舒张末期内径(LVEDD)和左心室射血分数(LVEF)与BNP的关系.结果 观察组总体血浆BNP水平明显高于对照组,两组比较差异有统计学意义(P＜0.05),美国纽约心脏病学会(NYHA)Ⅰ、Ⅱ、Ⅲ、Ⅳ级组间血浆BNP水平依次递增,经过纠正心力衰竭治疗后,各级心功能患者BNP、LVEDD均较治疗前显著减少(P＜0.05);LVEF较治疗前显著增高,与治疗前比较差异有统计学意义(P＜0.05).结论 血浆BNP水平可用于早期诊断慢性心力衰竭及其预后评估,且对舒张功能不全有较好的诊断价值.
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