Effect of hydromorphone hydrochloride combined with bupivacaine combined spinal-epidural anesthesia on serum pain mediators and placental hypoxia molecules after cesarean section

Xiao-Hui Yuan; Jian-Guo Xia; Xiao-Yang Jiang

首页> 中文期刊> 《海南医科大学学报(英文版)》 >Effect of hydromorphone hydrochloride combined with bupivacaine combined spinal-epidural anesthesia on serum pain mediators and placental hypoxia molecules after cesarean section

Effect of hydromorphone hydrochloride combined with bupivacaine combined spinal-epidural anesthesia on serum pain mediators and placental hypoxia molecules after cesarean section

开具论文收录证明 >>

期刊封面封底目录下载 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Objective:To study the effect of hydromorphone hydrochloride combined with bupivacaine combined spinal-epidural anesthesia on serum pain mediators and placental hypoxia molecules after cesarean section.Methods: 126 women accepting cesarean section in our hospital between May 2013 and December 2015 were selected as the research subjects and randomly divided into two groups, observation group of subjects received hydromorphone hydrochloride combined with bupivacaine combined spinal-epidural anesthesia and control group of subjects accepted bupivacaine combined spinal-epidural anesthesia. 1, 3 and 5 d after delivery, serum was collected to determine the levels of pain mediators;the placenta tissue was collected to detect the levels of oxidative stress molecules and endoplasmic reticulum stress molecules.Results: 1, 3 and 5 d after delivery, serum substance P (SP),β-endorphin (β-EP), 5-hydroxytryptamine (5-HT), nitric oxide (NO) and norepinephrine (NE) levels of observation group were significantly lower than those of control group whileβ-EP levels were significantly higher than those of control group (P<0.05);reactive oxide species (ROS), reactive nitrogen species (RNS), GRP78, ERdj1, CHOP and ASK1 levels in placenta tissue of observation group were significantly lower than those of control group while glutathione peroxidase (GPx), catalase (CAT) and vitamin C (VitC) levels were significantly higher than those of control group (P<0.05).Conclusions: Hydromorphone hydrochloride combined with bupivacaine combined spinal-epidural anesthesia can adjust the pain mediator secretion, relieve postoperative pain and inhibit oxidative stress and endoplasmic reticulum stress.

著录项

来源
《海南医科大学学报(英文版)》 |2017年第5期|P.148-151|共4页
作者
Xiao-Hui Yuan; Jian-Guo Xia; Xiao-Yang Jiang;
展开▼
作者单位

[1]Anesthesiology Department;

Wuhan Third Hospital in Hubei Province;

Wuhan 430000;

China;

[1]Anesthesiology Department;

Wuhan Third Hospital in Hubei Province;

Wuhan 430000;

China;

[1]Anesthesiology Department;

Wuhan Third Hospital in Hubei Province;

Wuhan 430000;

China;

展开▼
原文格式 PDF
正文语种 CHI
中图分类肿瘤学;
关键词
Cesarean section; Hydromorphone hydrochloride; Pain mediator; Oxidative stress; Endoplasmic reticulum stress;

机译：剖宫产盐酸氢吗啡酮疼痛介质氧化应激内质网应激;

Effect of hydromorphone hydrochloride combined with bupivacaine combined spinal-epidural anesthesia on serum pain mediators and placental hypoxia molecules after cesarean section

摘要

著录项

相关主题

期刊订阅