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《海南医科大学学报(英文版)》
>Effect of N-acetylcysteine on pulmonary fibrosis, endothelial injury and vasoactive factors in patients with chronic pulmonary heart disease
Effect of N-acetylcysteine on pulmonary fibrosis, endothelial injury and vasoactive factors in patients with chronic pulmonary heart disease
Objective:To study the effect of N-acetylcysteine on pulmonary fibrosis, endothelial injury and vasoactive factors in patients with chronic pulmonary heart disease.Methods:Patients with COPD complicated by chronic pulmonary heart disease who were treated in Zigong Third People''s Hospital between October 2015 and December 2016 were selected and randomly divided into two groups, NAC group received N-acetylcysteine combined with conventional therapy, and the control group received conventional therapy. Serum levels of pulmonary fibrosis indexes, endothelial injury and oxidative stress injury indexes and vasoactive factors were measured before and after treatment.Results:14 d and 28 d after treatment, serum TGF-β1,β-catenin, uPA, MMP7, ET-1, VEGF, IMD, ADM, MDA, 8-iso-PGF2 and AOPP levels of both groups of patients were significantly lower than those before treatment and serum TGF-β1,β-catenin, uPA, MMP7, ET-1, VEGF, IMD, ADM, MDA, 8-iso-PGF2 and AOPP levels of NAC group were significantly lower than those of control group.Conclusion:N-acetylcysteine can significantly inhibit pulmonary fibrosis, endothelial injury and vasoactive factor secretion in patients with chronic pulmonary heart disease.
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