首页> 中文期刊> 《海南医科大学学报(英文版)》 >Correlation between 25 hydroxyvitamin D3 and carotid atherosclerosis of newly diagnosed type 2 diabetes mellitus

Correlation between 25 hydroxyvitamin D3 and carotid atherosclerosis of newly diagnosed type 2 diabetes mellitus

         

摘要

Objective: To investigate the correlation between 25 hydroxyvitamin D3[25(OH)D3] and carotid atherosclerosis of newly diagnosed type 2 diabetes mellitus (T2DM). Methods: A total of 258 patients with newly diagnosed T2DM in this hospital between July 2015 and July 2017 were selected as T2DM group, and 100 subjects with normal glucose metabolism who received physical examination in this hospital during the same period were selected as normal control group. The differences in serum 25(OH)D3 levels, ultrasonic carotid atherosclerosis parameters as well as serum lipid metabolism index and inflammatory adipocytokines contents were compared between the two groups. Pearson test was used to assess the correlation between serum 25(OH)D3 level and carotid atherosclerosis in patients with newly diagnosed T2DM. Results: Serum 25(OH)D3 content of T2DM group was lower than that of normal control group;PWV and CC levels of the ultrasonic left and right carotid arteries were higher than those of normal control group;serum lipid metabolism indexes TC and LDL-C contents were higher than those of normal control group whereas HDL-C content was lower than that of normal control group;serum inflammatory cytokine APN content was lower than that of normal control group whereas CHEM, RSTN and LEP contents were higher than those of normal control group. Pearson test showed that serum 25(OH)D3 level in T2DM patients was directly correlated with the degree of carotid atherosclerosis. Conclusion: Serum 25(OH)D3 level is abnormally low in patients with newly diagnosed T2DM, and the specific decrease is directly correlated with the degree of carotid atherosclerosis and can be used as an early evaluation indicator for carotid artery disease in patients with T2DM.

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