Influence of polymyxin intravenous drip combined with aerosol inhalation on the inflammatory response process in patients with Acinetobacter baumannii infectious VAP

Yu-Jun Wang; Li Yu

首页> 中文期刊> 《海南医科大学学报(英文版)》 >Influence of polymyxin intravenous drip combined with aerosol inhalation on the inflammatory response process in patients with Acinetobacter baumannii infectious VAP

Influence of polymyxin intravenous drip combined with aerosol inhalation on the inflammatory response process in patients with Acinetobacter baumannii infectious VAP

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Objective: To explore the influence of polymyxin intravenous drip combined with aerosol inhalation on the inflammatory response process in patients with Acinetobacter baumannii infectious VAP. Methods: A total of 60 patients with Acinetobacter baumannii infectious VAP who received hospitalization in the hospital between January 2014 and January 2017 were collected and divided into control group and observation group by random number table, 30 cases in each group. Control group of patients received conventional therapy, observation group of patients received conventional therapy + polymyxin intravenous drip combined with aerosol inhalation, and the therapy lasted for 2 weeks. The differences in serum levels of acute phase proteins, oxidative stress indexes and inflammatory response indexes were compared between the two groups before and after treatment. Results: Before treatment, the differences in serum levels of acute phase proteins, oxidative stress indexes and inflammatory response indexes were not statistically significant between the two groups of patients. After 2 weeks of treatment, serum acute phase protein PA level of observation group was higher than that of control group while CRP and CER levels were lower than those of control group;serum oxidative stress indexes MDA and LHP levels were lower than those of control group while SOD level was higher than that of control group;serum inflammatory response indexes IL-1, IL-6, IL-8 and TNF-α levels were lower than those of control group. Conclusion: Polymyxin intravenous drip combined with aerosol inhalation can inhibit the systemic inflammatory response process and promote the disease recovery in patients with Acinetobacter baumannii infectious VAP.

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《海南医科大学学报(英文版)》 |2017年第19期|P.51-54|共4页
作者
Yu-Jun Wang; Li Yu;
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作者单位

[1]Department of Critical Care Medicine;

the Central Hospital of Wuhan;

Tongji Medical College;

Huazhong University of Science and Technology in Hubei Province;

Wuhan City;

Hubei Province;

430014;

[1]Department of Critical Care Medicine;

the Central Hospital of Wuhan;

Tongji Medical College;

Huazhong University of Science and Technology in Hubei Province;

Wuhan City;

Hubei Province;

430014;

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原文格式 PDF
正文语种 CHI
中图分类内科学;
关键词
Acinetobacter baumannii infectious; VAP; Polymyxin; Inflammatory response;

机译：鲍曼不动杆菌感染性;VAP;多粘菌素;炎症反应;

Influence of polymyxin intravenous drip combined with aerosol inhalation on the inflammatory response process in patients with Acinetobacter baumannii infectious VAP

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