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首页> 中文期刊> 《海南医科大学学报(英文版)》 >Value of HMGA2, Tiam1 and Notch1 expression for evaluating the malignant degree of non-small cell lung cancer

Value of HMGA2, Tiam1 and Notch1 expression for evaluating the malignant degree of non-small cell lung cancer

         
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摘要

Objective:To study the evaluation value of HMGA2, Tiam1 and Notch1 expression for cancer cell proliferation, invasion and epithelial-mesenchymal transition in non-small cell lung cancer tissue. Methods:Non-small cell lung cancer tissues and para-carcinoma tissues surgically removed in our hospital between May 2013 and December 2015 were collected, immunohistochemical staining method was used to determine HMGA2, Tiam1 and Notch1 protein expression, and fluorescence quantitative PCR was used to determine the mRNA expression of HMGA2, Tiam1, Notch1 as well as proliferation, invasion and epithelial-mesenchymal transition molecules. Results:HMGA2, Tiam1 and Notch1 mRNA expression and positive protein expression rate in lung cancer tissues were significantly higher than those in para-carcinoma tissues (P<0.05);E-cadherin mRNA expression in lung cancer tissues with positive HMGA2 expression was significantly lower than that in lung cancer tissues with negative HMGA2 expression (P<0.05) while N-cadherin and Vimentin mRNA expression were significantly higher than those in lung cancer tissues with negative HMGA2 expression (P<0.05);MMP2, MMP3, MMP8 and MMP9 mRNA expression in lung cancer tissues with positive Tiam1 expression were significantly higher than those in lung cancer tissues with negative Tiam1 expression (P<0.05);CyclinD1, Bcl-2 and Survivin mRNA expression in lung cancer tissues with positive Notch1 expression were significantly higher those in lung cancer tissues with negative Notch1 expression (P<0.05). Conclusions:Highly expressed HMGA2, Tiam1 and Notch1 in lung cancer tissues can regulate the epithelial-mesenchymal transition, invasion and proliferation of cancer cells respectively.

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  • 来源
    《海南医科大学学报(英文版)》 |2017年第3期|P.5-8|共4页
  • 作者

    Wei Li; Hong-Li Wang; Hong Li; Su Chen; Mei-Ying Yu; Qiu-Yuan Zhou; Yan-Hua Xu;

  • 作者单位

    [1]Department of Pathology;

    the Central Hospital of Enshi Autonomous Prefecture Hubei Province;

    Enshi 445000;

    China;

    [1]Department of Pathology;

    the Central Hospital of Enshi Autonomous Prefecture Hubei Province;

    Enshi 445000;

    China;

    [1]Department of Pathology;

    the Central Hospital of Enshi Autonomous Prefecture Hubei Province;

    Enshi 445000;

    China;

    [1]Department of Pathology;

    the Central Hospital of Enshi Autonomous Prefecture Hubei Province;

    Enshi 445000;

    China;

    [1]Department of Pathology;

    the Central Hospital of Enshi Autonomous Prefecture Hubei Province;

    Enshi 445000;

    China;

    [1]Department of Pathology;

    the Central Hospital of Enshi Autonomous Prefecture Hubei Province;

    Enshi 445000;

    China;

    [1]Department of Pathology;

    the Central Hospital of Enshi Autonomous Prefecture Hubei Province;

    Enshi 445000;

    China;

  • 原文格式 PDF
  • 正文语种 CHI
  • 中图分类 肿瘤学;
  • 关键词

    Lung cancer; HMGA2 Tiam1; Notch1; Proliferation; Invasion; Epithelial-mesenchymal transition;

    机译：肺癌;HMGA2 Tiam1;Notch1;增殖;侵袭;上皮-间质转化;
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