cqvip:Objective: To investigate the relationship between serum IDO levels and Treg/Th17, Th1/Th2 immune balance in patients with ulcerative colitis (UC). Methods: 78 cases of UC patients in our hospital during September 2015 to January 2018 were divided into Light UC group (n=42) and Severe UC group (n=36) according to severity of diarrhea. 50 cases of healthy volunteers underwent physical examination at the same time were selected as Normal control group. Serum contents of IDO, Treg, Th17, Th1, Th2-related cytokines were measured between three groups, the relationship between IDO and Treg/Th17, Th1/Th2 immune balance in UC patients was evaluated. Results: There were significant differences in serum contents of IDO, Treg, Th17, Th1, Th2 related cytokines among three groups (P<0.05). As aggravation of UC, serum content of IDO increased, contents of Treg cytokines IL-10, TGF-β decreased, contents of Th17 cytokines IL-17, IL-21 increased, contents of Th1 cytokines IL-2, IFN-γ increased, contents of Th2 cytokines IL-4, IL-13 decreased (P<0.05). Correlation analysis showed that serum IDO level was negatively correlated with Treg cytokines and positively correlated with Th17 cytokines, positively correlated with Th1 cytokines and negatively correlated with Th2 cytokines (P<0.05). Conclusion: Serum content of IDO in UC patients increases abnormally and is directly related to the immune balance of Treg/Th17 and Th1/Th2. It can be used as an effective index to evaluate the immune status of UC patients.
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