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《海南医科大学学报(英文版)》
>Effect of Shenkang granule combined with Atorvastatin on renal function, urinary protein and coagulation function in patients with chronic nephritis
Effect of Shenkang granule combined with Atorvastatin on renal function, urinary protein and coagulation function in patients with chronic nephritis
cqvip:Objective: To investigate the effect of Shenkang granule combined with Atorvastatin on renal function, urinary protein and coagulation function in patients with chronic nephritis. Methods:A total of 100 patients with chronic nephritis who were treated in our hospital between May 2016 to May 2017 were randomly divided into control group and observation group, 50 cases in each group. Patients in the control group were treated with Atorvastatin, while patients in the observation group were treated with Shenkang granule on the basis of the treatment in the control group. The changes of renal function, coagulation function and inflammatory factors were detected and compared between the patients in the two groups before and after treatment. Result: After treatment, the levels of Cr, BUN and 24hUpro in serum of patients in the two groups were significantly decreased, and the levels of ALB were significantly increased, and the changes of the above factors of patients in the observation group were more obvious. After treatment, the levels of PT, APTT and TT of patients in the two groups were significantly increased, and the levels of FIB were significantly decreased, and the changes of the above indexes of patients in the observation group were more obvious. After treatment, the levels of hs-CRP and TNF-α in serum of patients in the two groups were significantly decreased, and the decrease trend of inflammatory factors of patients in the observation group was more obvious. Conclusion: Shenkang granule combined with Atorvastatin has a good effect on treatment of chronic nephritis. It can significantly improve renal function and coagulation function, alleviate inflammation, and has a certain protective effect on kidney of patients.
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