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《海南医科大学学报(英文版)》
>Correlation of serum soluble adhesion molecules P-selectin and ICAM-1 with change of the illness in patients with chronic hepatitis B
Correlation of serum soluble adhesion molecules P-selectin and ICAM-1 with change of the illness in patients with chronic hepatitis B
cqvip:Objective:To explore the correlation of serum soluble adhesion molecules P-selectin and ICAM-1 with change of the illness in patients with chronic hepatitis B.Methods: 119 patients with chronic hepatitis B were divided into chronic hepatitis B group (n=83, patients with normal chronic hepatitis B) and severe hepatitis B group (n=36, patients with severe hepatitis B) according to the disease severity, and 50 healthy volunteers who received physical examination in our hospital during the same period were chosen as normal control group. The differences in serum soluble adhesion molecules P-selectin and ICAM-1, hepatitis B viral load (HBV-DNA), liver function indexes (AST, ALT, TP and TBil) as well as liver fibrosis indexes (CⅣ, HA and LN) were compared among the three groups, and the inner link of serum P-selectin and ICAM-1 contents with the above disease indexes in patients with chronic hepatitis B was further analyzed.Results: Serum P-selectin contents of chronic hepatitis B group and severe hepatitis B group were higher than that of normal control group respectively while ICAM-1 contents were lower than that of normal control group respectively, and the changes in serum P-selectin and ICAM-1 contents intensified as the patients' condition worsened. Serum HBV-DNA levels of chronic hepatitis B group and severe hepatitis B group were higher than that of normal control group respectively, and serum HBV-DNA level of severe hepatitis B group was higher;serum AST, ALT and TBil levels of severe hepatitis B group were higher than those of chronic hepatitis B group and normal control group while TP level was lower than that of chronic hepatitis B group and normal control group;serum CⅣ, HA and LN contents of chronic hepatitis B group and severe hepatitis B group were higher than those of normal control group respectively, and serum CⅣ, HA and LN contents of severe hepatitis B group were higher. Correlation analysis revealed that serum P-selectin and ICAM-1 contents in patients with chronic hepatitis B were directly correlated with hepatitis B viral load, liver function and liver fibrosis degree.Conclusion: Serum P-selectin content abnormally increases while ICAM-1 content abnormally decreases in patients with chronic hepatitis B, and their serum contents can be used to measure the disease severity.
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