cqvip:Objective:To investigate the methylation of the promoter region of microRNA-147 in glioma and its relationship with clinicopathological characteristics.Methods:Totally forty-five patients with glioma underwent surgical resection from November 2016 to September 2018 in the First Hospital of Shanxi Medical University,Affiliated Hospital of Shanxi Medical University.Methylation was detected by methylation-specific PCR(MSP).Results:Methylation was found in the promoter region of microRNA-147 in 30(66.7%)of 45 glioma patients,and methylation was not related to gender and age(P>0.05),but related to WHO classification(P<0.05).As a result,abnormal methylation of the promoter region of microRNA-147 may be one of the factors that affect the occurrence and development of glioma,and the higher the grade of glioma,the more prone the promoter region of microRNA-147 to methylation.
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