cqvip:Objective:To systematically identify the therapeutic effects of low-intensity laser with 830 nm on diabetic neuropathic pain.Methods:Thirty male SPF Wistar rats were equally assigned to the blank control(Control),diabetic neuropathic pain(DNP)and diabetic neuropathic pain exposed to the laser treatment(DNP+Laser)groups.The rats in the DNP group and DNP+Laser group were subjected to intraperitoneal injection with streptozotocin(STZ)to establish the diabetic animal model.The rats in the DNP+Laser group were exposed to laser stimulation(700 Hz,60 mW)with 3 sessions per day and 50 s per session for overall 8 weeks.The paw mechanical pain threshold levels and thermal pain threshold levels were measured at 0,2,4,6 and 8 weeks post the STZ administration,and the motor nerve conduction velocity and sensory nerve conduction velocity were also determined.Results:The rats in the DNP+EMF group showed significantly higher paw mechanical pain threshold levels and thermal pain threshold levels than the rats in the DNP group(P<0.05).Moreover,the motor nerve conduction velocity and sensory nerve conduction velocity in the DNP+Laser group were also significantly higher than those in the DNP group(P<0.05).Conclusion:Low-intensity laser stimulation displayed positive effects on the attenuation of the progression of neuropathic pain in diabetic rats,implying that low-intensity laser treatment has the potential to be an effective biophysical approach for diabetic neuropathic pain in clinics.
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