• 主题
高级搜索  >
历史搜索 清空历史
首页> 中文期刊> 《海南医科大学学报(英文版)》 >Therapeutic efficacy of traditional Chinese medicine compound in the treatment of membranous nephropathy: A systematic review and meta-analysis

Therapeutic efficacy of traditional Chinese medicine compound in the treatment of membranous nephropathy: A systematic review and meta-analysis

         
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

Objective:Systematic review of the clinical efficacy of medicinal nephropathy in the treatment of membranous nephropathy with the addition of traditional Chinese herbal compound on the basis of hormone and immunosuppressive therapy.Methods:Computer search of China Knowledge Network,Wanfang Database,Weipu Database,China Biomedical Database,PubMed Database、Embase Database、Cochrane Database,collect clinical research on Chinese medicine compound+hormone+immunosuppressive therapy for MN,delete duplicate literature,eliminate non-conformity by reading topic,abstract and full text The literature was included in the exclusion criteria,the data was extracted from the included literature,and the meta-analysis was performed using the stata14.0 software package.Results:The top 6 Chinese medicines used were Astragalus,Poria,Atractylodes,Salvia,Angelica and Chinese Yam.The use of traditional Chinese medicine in the treatment of patients with MN on the basis of hormone and immunosuppressive therapy can improve clinical efficacy[OR=2.90,95%CI(2.27,3.70),P<0.00001]and TCM symptom efficacy[OR=3.10,95%CI(1.91,5.05),P<0.00001],improved TCM syndrome scores[SMD=-0.93,95%CI(-1.34,-0.52),P<0.00001],reduced 24-hour urine protein levels[SMD=-0.90,95%CI(-1.23,-0.57),P<0.00001],increased plasma albumin levels[SMD=1.22,95%CI(0.86,1.58),P=0.000],decreased blood lipid TC levels[SMD=-0.69,95%CI(-0.98,-0.39),P<0.00001],lowering blood lipid TG levels[SMD=-0.75,95%CI(-1.09,-0.41),P<0.0001],in improving renal function BUN levels[SMD=-0.56,95%CI(-0.97,0.14),P=0.008]and Scr levels[SMD=-0.58,95%CI(-0.89,-0.27),P=0.0002],reducing the incidence of adverse reactions[OR=0.25,95%CI(0.17,0.36),P<0.00001].Egger and harbord test results suggest that some indicators have publication bias.Conclusion:The traditional Chinese medicine used is mainly jaundice,and the traditional Chinese medicine for replenishing qi and activating blood is used more frequently.In the basic application of hormone+immunosuppressive agents,Yiqihuoxue Chinese medicine has a good effect on MN,but it is limited to the quality of the included literature.The conclusion needs to be verified by more high-quality studies.

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号