Objective To analyze relapse risks between alcohol dependence patients. Methods 228 alcohol dependence patients who match the CCMD3 diagnosis were collected,and divided into multiplexed group (128 cases) and nonmultiplexed drink group(100 cases) by multiplexed drink or not in last year. Demographic data, Eysenck Personality Inventory (EPQ below), Hamilton Depres-sion Scale (HAMD below), Life Events Scale (LES below), Social Support Rating Scale (SSRS be-low), family intimacy degree and adaptability scale (FACES ⅡCV) were analyzed by t test,Chi-square test for comparison. Then grouped as the dependent variable, variables which has a statisti-cally significant as independent variables were analyzed for multivariate logistic regression. Results The result suggested that the scores of EPQP, EPQN, HAMD, life events and negative events, SSRS support, objective support, subjective support, FACESⅡCV intimacy, adaptability and the values of educational years, length of drinking alcohol,quantity of drink with a statistically signif-icant(P<0.05). A nonconditional logistic regression model was developed.Regression suggested that negative events, EPQP scores, HAMD scores were risk factors, and the subjective support and EY were protective factors, B coefficient were 0.325, 0.417, 0.235,-0.286,-0.471, respectively. All the regression coefficients with statistical significance(P<0.05). Years of education were as a protec-tive factor, B is -0.471. Conclusion Clinical studies suggested that patients with multiplexed drink had a bad personality, depression characteristics, negative events in the multiplexed highrisk. Patients with a high level of culture and education, may be beneficial to understanding phys-ical, psychological harm brings by alcohol dependence. Improving symptoms of depression targeted, bad behavior patterns that may relieve the risk of multiplexed drink.%目的对照分析酒依赖综合征复饮的危险因素。方法收集符合CCMD-3诊断的酒依赖综合征228例，并按过去1年内是否有复饮分为复饮组（128例）及非复饮组（100例）。通过对照并采用t检验、卡方检验等分析人口学资料、艾森克个性量表（EPQ下同）、汉密尔顿抑郁量表（HAMD下同）、生活事件量表（LES 下同）、社会支持评定量表（SSRS下同）、家庭亲密度和适应性量表（FACESⅡCV）。再以分组为因变量，以有统计学显著意义的变量为自变量进行多因素非条件logistic回归分析。结果两组的EPQP、EPQN、HAMD、LES的生活事件及负性事件得分，SSRS的支持、客观支持、主观支持分，FACESⅡCV的亲密度、适应性得分、受教育年限、饮酒年限、饮酒数量均有显著意义。以分组为因变量，分别以P<0.05的人口学资料变量、临床特征加社会心理因素变量为自变量进行多因素非条件lo-gistic回归分析。提示负性事件、EPQP分数、HAMD分数为复饮的危险因素，回归系数B分别为0.325、0.417、0.235，而教育年限为保护因素，B为0.471。上述B均有统计学意义（P<0.05）。回归的Nagelkerke R2的估计值为0.840，提示该回归模型拟合性好。结论研究提示复饮病人临床有不良人格、抑郁特征，在负性事件影响下复饮风险高，患者高文化教育水平，可能有利于认识酒依赖带来的生理、心理危害，同时有针对性的改善抑郁症状、不良行为模式可能缓解复饮的风险。
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