Objective To determine the risk factors for acute upper gastrointestinal hemorrhage in pa-tients with COPD respiratory failure treated by FMMV, and to find targeted preventive measures. Method In this retrospective case-control study, single factor analysis (counting data by chi square test, rank data by rank sum test) and multivariate analysis (binary logistic regression analysis) were performed in order to determine the risk factors and fit the prediction equation. Result The pH value which was less than or equal to 7.2 and se-rious infection were risk factors for acute upper gastrointestinal hemorrhage in patients with COPD respiratory failure treated by FMMV. Fitting prediction equation was found to be 2.533-2.503 pH (P) -1.753 value of Logit severe infection. Conclusion The complication of upper gastrointestinal bleeding in treating the respira-tory failure of COPD with FMMV can be avoided by correcting the pH value and severe infection according to the fitting equation.%目的 确定FMMV治疗COPD呼吸衰竭并发急性上消化道出血的危险因素,采取有针对性的预防措施.方法 分别进行单因素分析(计数资料卡方检验;等级资料秩和检验)和多因素分析(二元Logistic回归分析),以确定危险因素并拟合预测判断方程.结果 pH值≤7.2和严重感染,是导致FMMV治疗COPD呼吸衰竭并发上消化道出血的危险因素;拟合预测判断方程为Logit(P)=2.533-2.503 pH值-1.753严重感染.结论 FMMV治疗COPD呼吸衰竭并发上消化道出血,应尽量避免及时纠正pH值≤7.2和严重感染;可根据拟合方程logit(P)=2.533-2.503 pH值-1.753严重感染,进行高危患者的预测判断[logit(P)>0.5];针对性预防用药采用硫糖铝等胃黏膜保护剂,注意避免使用抑酸剂.
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