Objective It is to observe the influence of Xiaochaihu Decoction on serum total bile acid and the serum fibro-blast growth factor19 (FGF19) expression in cholelith disease patients with liver stagnation and Qi stagnation type.Methods A randomized controlled clinical trial method, 60 cholelith disease patients with liver stagnation and Qi stagnation type were di-vided into treatment group (30 cases), control group (30 cases).The patients were treated by oral administration of Xi-aochaihu Decoction for 60 days in treatment group, and by drinking a cup of warm water in morning and evening a day for 60 days.On the day of surgery and postoperative 30th, 60th days, the total bile acid concentration was detected by enzymatic as-say, and the FGF19 concentration was detected by enzyme-linked immunosorbent method.Results By treated for 60 days, the serum concentration of total bile acid and FGF19 of treatment group were markedly higher than before treatment and the control group (all P<0.05).Conclusion Xiaochaihu Decoction can be effectively adjust the content of serum bile acid and FGF19, thus inhibiting gallstone formation;Its action to promote bile acid secretion and inhibit FGF19 metabolic expression are better than the action of FGF19 secretion of bile acids promote.%目的：观察小柴胡汤加减方对肝郁气滞型胆石症患者血清总胆汁酸、成纤维细胞生长因子19（ FGF19）表达的影响。方法采用随机对照的临床试验方法，将60例肝郁气滞型胆石症患者分为试验组30例、对照组30例。从术后3 d开始，试验组口服小柴胡汤加减方，早晚各饮50 mL，共60 d；对照组早晚各饮温水1杯，共60 d。分别于手术当天、术后第30天、术后第60天采用酶法检测患者总胆汁酸浓度，用酶联免疫吸附法检测患者FGF19浓度。结果试验组术后第60天血清总胆汁酸浓度、血清FGF19浓度均明显高于术前及对照组（ P均＜0．05）。结论小柴胡汤加减方能够有效调节血清总胆汁酸和血清FGF19浓度，从而抑制胆石形成。小柴胡汤加减方促进胆汁酸分泌作用联合抑制FGF19的代谢表达作用强于胆汁酸对FGF19分泌的促进作用。
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