目的：观察医用臭氧对慢性乙型肝炎患者HBeAg、HBsAg及瞬时肝弹性测定（FibroScan）的影响，评估医用臭氧在慢性乙型肝炎患者中的抗病毒、抗纤维化作用。方法将120例HBeAg阳性的慢性乙肝患者随机分成2组，治疗组给予医用臭氧自体血回输治疗（采集患者静脉抗凝全血100 mL，在其中缓慢注入100 mL 30μg／mL医用臭氧，然后再回输到静脉），每周3次；对照组给予聚乙二醇干扰素α－2 a 180μg皮下注射，每周1次。观察2组治疗4周、8周、12周时血清HBsAg、HBeAg定量及FibroScan的变化。结果2组在治疗4周、8周、12周时血清HBsAg、HBeAg定量及FibroScan均逐渐下降（P均＜0．05）；2组间各指标比较差异无统计学意义（P均＞0．05）；患者血清HB-sAg定量、HBeAg定量与FibroScan之间呈正相关（r＝0．764，0．779，P均＜0．05）。结论医用臭氧自体血回输治疗慢性乙型肝炎与聚乙二醇干扰素α－2a效果相当，其抗病毒、抗纤维化效果确切。%Objective It is to observe the influence of medical ozone on HBeAg , HBsAg and transient liver elasticity ( Fi-broScan ) in patients with chronic hepatitis B , and evaluate the antiviral and anti fibrosis effects of medical ozone in the treat -ment of chronic hepatitis B patients .Methods 120 patients with HBeAg positive chronic hepatitis B were randomly divided in-to two groups.The patients in the treatment group was treated with medical ozone autologous blood transfusion (anticoagulant venous blood 100 mL was collected from patients , which was slowly injected into the 100 mL 30μg/mL of medical ozone , and then returned to the vein ) , three times a week;the patients in the control group were treated with the polyethylene glycol inter -feron α-2a 180 μg by subcutaneous injection , once a week.The changes of serum HBeAg , HBsAg quantification and Fi-broScan value in the treatment of 4 weeks, 8 weeks, and 12 weeks were observed.Results The serum HBsAg, HBeAg quanti-fication and FibroScan value in the treatment of 4 weeks, 8 weeks, 12 weeks were gradually decreased in the two groups (all P<0.05);and there was no significant difference between the two groups (P>0.05).There was positive correlation between serum HBsAg, HBeAg quantification with FibroScan value (r=0.764, 0.779, all P<0.05).Conclusion The effcet of med-ical ozone autologous blood transfusionin in the treatment of chronic hepatitis B is similar to polyethylene glycol interferon α-2a, and it has the definite effect of anti viral and anti fibrosis .
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