目的 研究三七总皂苷(PNS)对庆大霉素所致大鼠急性肾损伤的保护作用.方法 腹腔注射庆大霉素致大鼠急性肾损伤模型,同时肌肉注射PNS治疗10 d,观察尿液中尿蛋白、葡萄糖、酮体的变化,血液中肌酐、尿素氮、总蛋白和白蛋白的变化及肾组织的病理改变.结果 与模型组比较,PNS组尿液中蛋白、酮体、葡萄糖水平及血液中肌酐、尿素氮、总蛋白和白蛋白水平明显降低.结论 PNS对庆大霉素诱发大鼠急性肾损伤有明显保护作用.%Objective It is to study the protecting effects of panax notoginseng saponins ( PNS ) on acute kidney injury caused by gentamicin in rats. Methods The acute kidney injury models of rats were established by giving gentamicin hy intraperitoneal injection. At the same times, the rats were treated with PNS hy intramscular injection for 10 days. The changes of urine protein, glucose, ketones in urine, and creatinine, hlood urea nitrogen, total protein album in blood and the pathologic changes of kidney tissue were ohserved. Results Compared with those in model group, the levels of urine protein, glucose,ketones in urine, creatinine, blood urea nitrogen, total protein and album in blood were obviously decreased. Conclusion PNS has a significant protecting effect on acute kidney injury caused by gentamicin in rats.
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