建立了高效液相色谱同时测定减肥药中奥利司他、东布曲明、西布曲明、利莫那班4种违禁药物成分的方法。采用Thermo C18（4.6×250 mm,5μm）色谱柱,以0.02mol/L的磷酸二氢钾和乙腈为流动相,梯度洗脱,流速为1.0 mL/min,柱温30℃,检测波长为222 nm。奥利司他、东布曲明、西布曲明、利莫那班回收率分别为89.1-98.7%。本方法简便快速,结果准确可靠。%A HPLC method for the simultaneous determination of orlistat,doivutramine,sibutramine and rimonabant,which are contraband medicine component in the health food for controlling body weight,is established.The four components could be separated completely on a Thermo C18 column（4.6×250 mm,5μm）,then were detected at 222nm,using acetonitrile and 0.02mol/L dihydrogen phosphate solution with gradient elution as the mobile phase at flow rate 1.0 mL/min,and the column temperature was 30°C.The average recoverys for real samples ranged form 89.1-98.7%.The method is simple,rapid,accurate and reliable.
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