Use of the Metabolomics Approach to Characterize Chinese Medicinal Material Huangqi

Li-Xin Duan; Xiaoquan Qi; Tian-Lu Chen; Ming Li; Min Chen; Ye-Qing Zhou; Guang-Hong Cui; Ai-Hua Zhao; Wei Jia; Lu-Qi Huang

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Use of the Metabolomics Approach to Characterize Chinese Medicinal Material Huangqi

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Integration of the genetic and metabolic fingerprinting can provide a new approach to differentiate similar Traditional Chinese Medical (TCM) materials.Two leguminous plants,Mojia Huangqi and Menggu Huangqi,are important medical herbs and share great similarities in morphology,chemical constituent,and genomic DNA sequence.The taxonomy of Mojia Huangqi and Menggu Huangqi has been debated for more than 50 years and discrimination of TCM materials directly affects the pharmacological and clinical effects.AFLP based genetic fingerprinting and GC-TOF/MS-based metabolic fingerprinting were used to successfully discriminate the two species.The results of AFLP supported the opinion that Menggu Huangqi was a variant of Mojia Huangqi.The metabolic fingerprinting showed growth locations have greater impacts on the metabolite composition and quantity than the genotypes (cultivated versus wild) in Menggu Huangqi.The difference of some soluble sugars,fatty acids,proline,and polyamine reflected plant adaptation to different growth environments.Using multivariate and univariate statistical analysis,three AFLP markers and eight metabolites were identified as candidate DNA and metabolic markers to distinguish the two herb materials.The correlation network between AFLP markers and metabolites revealed a complex correlation network,which indicated the special metabolic pathways and the regulation networks of Huangqi.

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《分子植物（英文版）》 |2012年第2期|376-386|共11页
作者
Li-Xin Duan; Xiaoquan Qi; Tian-Lu Chen; Ming Li; Min Chen; Ye-Qing Zhou; Guang-Hong Cui; Ai-Hua Zhao; Wei Jia; Lu-Qi Huang;
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The Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, 20 Nanxincun Xiangshan Road, Beijing 100093, China;

The Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, 20;

Shanghai Center for Systems Biomedicine(Ministry of Education Key Laboratory of Systems Biomedicine), Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China;

The Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, 20 Nanxincun Xiangshan Road, Beijing 100093, China;

Institute of Chinese Materia Medica, Chinese Academy of Chinese Medical Sciences, 16 Nanxiao Road, Beijing 100700, China;

The Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, 20 Nanxincun Xiangshan Road, Beijing 100093, China;

Institute of Chinese Materia Medica, Chinese Academy of Chinese Medical Sciences, 16 Nanxiao Road, Beijing 100700, China;

School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China;

Shanghai Center for Systems Biomedicine(Ministry of Education Key Laboratory of Systems Biomedicine), Shanghai Jiao Tong University, 800 Dongchuan;

Institute of Chinese Materia Medica, Chinese Academy of Chinese Medical Sciences, 16 Nanxiao Road, Beijing 100700, China;

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Use of the Metabolomics Approach to Characterize Chinese Medicinal Material Huangqi

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