Aqueous Self-Assembly of Block Copolymers to Form Manganese Oxide-Based Polymeric Vesicles for Tumor Microenvironment-Activated Drug Delivery

Yalei Miao; Yudian Qiu; Mengna Zhang; Ke Yan; Panke Zhang; Siyu Lu; Zhongyi Liu; Xiaojing Shi; Xubo Zhao

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Aqueous Self-Assembly of Block Copolymers to Form Manganese Oxide-Based Polymeric Vesicles for Tumor Microenvironment-Activated Drug Delivery

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Molecular self-assembly is crucially fundamental to nature.However,the aqueous self-assembly of polymers is still a challenge.To achieve self-assembly of block copolymers [(polyacrylic acid-block-polyethylene glycol-block-polyacrylic acid(PAA68-b-PEG86-b-PAA68)] in an aqueous phase,manganese oxide(MnO2) is first generated to drive phase separation of the PAA block to form the PAA68-b-PEG68-b-PAA68/MnO2 polymeric assembly that exhibits a stable structure in a physiological medium.The polymeric assembly exhibits vesicular morphology with a diameter of approximately 30 nm and high doxorubicin(DOX) loading capacity of approximately 94%.The transformation from MnO2 to Mn2+caused by endogenous glutathione(GSH)facilitates the disassembly of PAA68-b-PEG68-b-PAA68/MnO2 to enable its drug delivery at the tumor sites.The toxicity of DOXloaded PAA68-b-PEG68-b-PAA69/MnO2 to tumor cells has been verified in vitro and in vivo.Notably,drug-loaded polymeric vesicles have been demonstrated,especially in in vivo studies,to overcome the cardiotoxicity of DOX.We expect this work to encourage the potential application of polymer self-assembly.

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《纳微快报：英文版》 |2020年第9期|P.324-338|共15页
作者
Yalei Miao; Yudian Qiu; Mengna Zhang; Ke Yan; Panke Zhang; Siyu Lu; Zhongyi Liu; Xiaojing Shi; Xubo Zhao;
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Green Catalysis Center College of Chemistry and Laboratory Animal Center Zhengzhou University Zhengzhou 450001 People’s Republic of China;

Green Catalysis Center College of Chemistry and Laboratory Animal Center Zhengzhou University Zhengzhou 450001 People’s Republic of China;

Green Catalysis Center College of Chemistry and Laboratory Animal Center Zhengzhou University Zhengzhou 450001 People’s Republic of China;

Green Catalysis Center College of Chemistry and Laboratory Animal Center Zhengzhou University Zhengzhou 450001 People’s Republic of China;

Green Catalysis Center College of Chemistry and Laboratory Animal Center Zhengzhou University Zhengzhou 450001 People’s Republic of China;

Green Catalysis Center College of Chemistry and Laboratory Animal Center Zhengzhou University Zhengzhou 450001 People’s Republic of China;

Green Catalysis Center College of Chemistry and Laboratory Animal Center Zhengzhou University Zhengzhou 450001 People’s Republic of China;

Green Catalysis Center College of Chemistry and Laboratory Animal Center Zhengzhou University Zhengzhou 450001 People’s Republic of China;

Green Catalysis Center College of Chemistry and Laboratory Animal Center Zhengzhou University Zhengzhou 450001 People’s Republic of China;

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原文格式 PDF
正文语种 chi
中图分类高分子化学（高聚物）;
关键词
Polymer; Aqueous self-assembly; Vesicles; Tumor microenvironment; Drug delivery system;

机译：聚合物;水自组装;囊泡;肿瘤微环境;药物输送系统;

Aqueous Self-Assembly of Block Copolymers to Form Manganese Oxide-Based Polymeric Vesicles for Tumor Microenvironment-Activated Drug Delivery

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