Cyanidin suppresses amyloid beta-induced neurotoxicity by inhibiting reactive oxygen species-mediated DNA damage and apoptosis in PC12 cells

Yi Wang; Nam Chun Cho; Xiao-ting Fu; Da-wei Li; Kun Wang; Xin-zhi Wang; Yuan Li; Bao-liang Sun; Xiao-yi Yang; Zun-cheng Zheng

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Cyanidin suppresses amyloid beta-induced neurotoxicity by inhibiting reactive oxygen species-mediated DNA damage and apoptosis in PC12 cells

机译：氰胺素通过抑制活性氧介导的DNA损伤和PC12细胞凋亡来抑制淀粉样β诱导的神经毒性

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Amyloid beta (Aβ)-induced oxidative stress is a major pathologic hallmark of Alzheimer’s disease. Cyan-idin, a natural lfavonoid compound, is neuroprotective against oxidative damage-mediated degeneration. However, its molecular mechanism remains unclear. Here, we investigated the effects of cyanidin pretreat-ment against Aβ-induced neurotoxicity in PC12 cells, and explored the underlying mechanisms. Cyanidin pretreatment signiifcantly attenuated Aβ-induced cell mortality and morphological changes in PC12 cells. Mechanistically, cyanidin effectively blocked apoptosis induced by Aβ, by restoring the mitochondrial mem-brane potentialvia upregulation of Bcl-2 protein expression. Moreover, cyanidin markedly protected PC12 cells from Aβ-induced DNA damage by blocking reactive oxide species and superoxide accumulation. These results provide evidence that cyanidin suppresses Aβ-induced cytotoxicity, by preventing oxidative damage mediated by reactive oxide species, which in turn inhibits mitochondrial apoptosis. Our study demonstrates the therapeutic potential of cyanidin in the prevention of oxidative stress-mediated Aβ neurotoxicity.

机译：淀粉样蛋白β（Aβ）诱导的氧化胁迫是阿尔茨海默病的主要病理标志。天然LFAVONOID化合物是抗氧化损伤介导的变性的青色念珠菌是神经保护性的。然而，其分子机制仍不清楚。在这里，我们研究了Cyanidin预处理对PC12细胞中的β-诱导神经毒性的影响，并探索了潜在机制。 Cyanidin预处理意义显着衰减PC12细胞的β诱导的细胞死亡率和形态学变化。机械上，Cyanidin通过恢复Bcl-2蛋白表达的线粒体Mem-Brane iscoplyvia上调来有效地阻断了Aβ诱导的凋亡。此外，Cyanidin通过阻断反应性氧化物物质和超氧化物积累，从Aβ诱导的DNA损伤明显保护PC12细胞。这些结果提供了Cyanidin通过防止由反应氧化物物种介导的氧化损伤来抑制Aβ诱导的细胞毒性，这反过来抑制线粒体细胞凋亡。我们的研究表明，Cyanidin在预防氧化应激介导的Aβ神经毒性方面的治疗潜力。

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《中国神经再生研究（英文版）》 |2016年第5期|795-800|共6页
作者
Yi Wang; Nam Chun Cho; Xiao-ting Fu; Da-wei Li; Kun Wang; Xin-zhi Wang; Yuan Li; Bao-liang Sun; Xiao-yi Yang; Zun-cheng Zheng;
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Department of 0phthalmology, Chonbuk National University Medical College, Jeonju-si, Jeollabuk-do, Republic of Korea;

Department of 0phthalmology, Chonbuk National University Medical College, Jeonju-si, Jeollabuk-do, Republic of Korea;

Key Lab of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong Province, China;

Key Lab of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong Province, China;

Key Lab of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong Province, China;

Key Lab of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong Province, China;

Key Lab of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong Province, China;

Key Lab of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong Province, China;

Key Lab of Cerebral Microcirculation in Universities of Shandong, Taishan Medical University, Taian, Shandong Province, China;

Department of Rehabilitation, Taian Central Hospital, Taian, Shandong Province, China;

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收录信息中国科学引文数据库(CSCD);中国科技论文与引文数据库(CSTPCD);
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Cyanidin suppresses amyloid beta-induced neurotoxicity by inhibiting reactive oxygen species-mediated DNA damage and apoptosis in PC12 cells

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