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Middle cerebral artery occlusion methods in rat versus mouse model of transient focal cerebral ischemic stroke

         

摘要

Experimental stroke research commonly employs focal cerebra ischemic rat models(Bederson et al.,1986a;Longa et al.,1989).In human patients,ischemic stroke typically results from thrombotic or embolic occlusion of a major cerebral artery,usually the middle cerebral artery(MCA).Experimental focal cerebral ischemia models have been employed to mimic human stroke(Durukan and Tatlisumak,2007).Rodent models of focal cerebral ischemia

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