Dynamic expression of cerebral cortex and hippocampal glutamate transporters in a rat model of chest compression-induced global cerebral ischemia

Qinhua Guo; Jin Lan; Weiqiao Zhang; Pin Guo; Liemei Guo; Zhiqiang Li; Yongming Qiu

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Dynamic expression of cerebral cortex and hippocampal glutamate transporters in a rat model of chest compression-induced global cerebral ischemia

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The present study established a rat model of global cerebral ischemia induced by chest compression for six minutes to dynamically observe expressional changes of three glutamate transporters in the cerebral cortex and hippocampus. After 24 hours of ischemia, expression of glutamate transporter-1 significantly decreased in the cerebral cortex and hippocampus, which was accompanied by neuronal necrosis. At 7 days post-ischemia, expression of excitatory amino acid carrier 1 decreased in the hippocampal CA1 region and cortex, and was accompanied by apoptosis. Expression of glutamate-aspartate transporter remained unchanged at 6 hours-7 days after ischemia. These results suggested that glutamate transporter levels were altered at different periods of cerebral ischemia.

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《中国神经再生研究：英文版》 |2012年第2期|125-130|共6页
作者
Qinhua Guo; Jin Lan; Weiqiao Zhang; Pin Guo; Liemei Guo; Zhiqiang Li; Yongming Qiu;
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作者单位

Department of Neurosurgery;

Renji Hospital;

Shanghai Jiao Tong University School of Medicine;

Shanghai 200127;

China;

Central Hospital of Fengxian District;

Shanghai Neurological Research Institute of Anhui University of Science ＆ Technology;

Shanghai201400;

China;

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原文格式 PDF
正文语种 chi
中图分类啮齿目;
关键词
谷氨酸转运体; 海马CA1区; 大鼠模型; 大脑皮质; 脑缺血; 诱导; 动态表; 胸部;

Dynamic expression of cerebral cortex and hippocampal glutamate transporters in a rat model of chest compression-induced global cerebral ischemia

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