Icariin upregulates phosphorylated cyclic adenosine monophosphate response element binding protein levels in the hippocampus of the senescence-accelerated mouse

Zhanwei Zhang; Ting Zhang; Keli Dong

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Icariin upregulates phosphorylated cyclic adenosine monophosphate response element binding protein levels in the hippocampus of the senescence-accelerated mouse

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At 8 weeks after intragastric administration of icariin to senescence-accelerated mice (P8 strain), Morris water maze results showed that escape latency was shortened, and the number of platform crossings was increased. Immunohistochemical staining and western blot assay detected significantly increased levels of cyclic adenosine monophosphate response element binding protein. These results suggest that icariin upregulates phosphorylated cyclic adenosine monophosphate response element binding protein levels and improves learning and memory functions in hippocampus of the senescence-accelerated mouse.

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《中国神经再生研究：英文版》 |2012年第12期|885-890|共6页
作者
Zhanwei Zhang; Ting Zhang; Keli Dong;
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作者单位

Department of Neurosurgery;

First Affiliated Hospital;

Hunan University of Chinese Medicine;

Changsha 410007;

Hunan Province;

China;

Department of Traditional Chinese Medicine;

Third Xiangya Hospital;

Central South University;

Changsha 410013;

Hunan Province;

China;

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原文格式 PDF
正文语种 chi
中图分类各种家畜、家禽、野生动物的疾;
关键词
蛋白水平; 衰老小鼠; 淫羊藿苷; 反应元件; 磷酸反应; 海马; Morris水迷宫; 环磷酸腺苷;

Icariin upregulates phosphorylated cyclic adenosine monophosphate response element binding protein levels in the hippocampus of the senescence-accelerated mouse

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