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首页> 中文期刊> 《中国神经再生研究：英文版》 >Plasma fibrinogen beta-148C/T gene polymorphism in cerebral infarction patients

Plasma fibrinogen beta-148C/T gene polymorphism in cerebral infarction patients

         
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摘要

BACKGROUND: Plasma fibrinogen (Fg) β-148C/T gene polymorphism is a risk factor for ischemic angiopathy. OBJECTIVE: To explore the frequency distribution of Fg β-148C/T gene polymorphism and its relationship with plasma Fg levels in patients with cerebral infarction. DESIGN, TIME AND SETTING: Case control experiment of gene polymorphism was performed at the Central Laboratory of Qingdao University Medical College from January 2003 to June 2004. PARTICIPANTS: A total of 88 patients with cerebral infarction were recruited from the Affiliated Hospital of Qingdao University Medical College, including 52 males and 36 females, averaging (61 ± 14) years of age. In addition, 80 healthy cases served as the control group, comprising 48 males and 32 females, with an average age of (58 ± 12) years. METHODS: Blood DNA was extracted, and electrophoresis results were observed using an ultraviolet single photon image system. The frequency distribution of Fg β-148C/T was analyzed by polymerase chain reaction-restriction fragment length polymorphism method. Plasma Fg levels were measured by cerebral infarction time. MAIN OUTCOME MEASURES: Plasma Fg β-148C/T gene polymorphism and plasma Fg levels in patients with cerebral infarction. RESULTS: The frequency of the T allele, and plasma Fg levels in CC, CT, and CC+CT genotype subgroup, were significantly greater in the cerebral infraction group, compared with the control group (P 0.05). The plasma Fg levels in the CT, TT, and CT+TT genotype groups were significantly greater than the CC genotype group (P < 0.05). However, in the control group, plasma Fg levels in the TT genotype subgroup were significantly greater than the remaining genotype subgroups (P < 0.05). CONCLUSION: Plasma Fg β-148C/T gene polymorphism is an important hereditary factor for differences in plasma Fg levels. The T allele plays a crucial role in influencing plasma Fg levels in cerebral infarction. Fg β-148C/T may be a susceptibility factor for cerebral infarction.

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