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首页> 中文期刊> 《中国神经再生研究：英文版》 >Effects of long-term sustained naltrexone release on the optic center in opioid-dependent patients Case-control study in four provinces of China

Effects of long-term sustained naltrexone release on the optic center in opioid-dependent patients Case-control study in four provinces of China

         
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Very little is known about visual functional recovery following long-term naltrexone administration in opioid-dependent patients.In the present study,a portable event-related potential(ERP) working system was utilized to collect and record ERP in opioid-dependent patients and normal controls in visual half-field testing.In addition,the influence of long-term sustained naltrexone release on the visual nervous system was observed in opioid-dependent patients.Results revealed a significant main group effect in reaction time to visual signal stimulations.The reaction time of normal controls was shortest,but longest in opioid-dependent patients.The reaction time of long-term sustained naltrexone release group and compulsory detoxification group was similar to normal controls.A significant main group effect was also observed in P100 latency,and P100 latency in normal controls and the compulsory detoxification group was significantly decreased compared with the opioid-dependent patients.P100 amplitude at the Oz-electrode resulted in a significant main group effect.In particular,normal controls exhibited significant differences compared with long-term sustained release naltrexone and compulsory detoxification groups.These findings demonstrated that long-term sustained naltrexone release effectively ameliorated optic center function and improved visual sensitivity and reactions in opioid-dependent patients.

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