Pharmacological interventions targeting nuclear factor-kappa B signaling in multiple sclerosis

Kim M.A.De Kleijn; Gerard J.M.Martens

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Pharmacological interventions targeting nuclear factor-kappa B signaling in multiple sclerosis

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Multiple sclerosis(MS)is an inflammatory neurodegenerative disease of the central nervous system(CNS).Pathological characteristics of the disease include activation of CNS-intrinsic immune cells,such as microglia and astrocytes,and loss of neuronal connections,myelin and blood-brain barrier(BBB)integrity as well as peripheral immune cell infiltration into the brain.MS has long been considered a predominantly immunological disease,which has led to the development of essentially only immune-directed medications.Within this traditional“outside-in”MS hypothesis,a dysregulation of the peripheral immune system causes immune cell infiltration into the CNS,leading to autoreactivity against myelin sheath components and secondary BBB dysfunction.However,recent findings indicate that overactivation of microglia and astrocytes represents an important first step in MS pathology,as appears to be the case for other neurodegenerative diseases such as Alzheimer’s disease(AD)and Parkinson’s disease(PD).

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《中国神经再生研究：英文版》 |2021年第10期|2023-2025|共3页
作者
Kim M.A.De Kleijn; Gerard J.M.Martens;
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作者单位

Department of Molecular Animal Physiology;

Donders Institute for Brain;

Cognition and Behaviour;

Centre for Neuroscience;

Faculty of Science;

Radboud University;

6525AJ Nijmegen;

The Netherlands;

NeuroDrug Research Ltd;

6525ED Nijmegen;

The Netherlands(De Kleijn KMA;

Martens GJM)Department of Molecular Animal Physiology;

Donders Institute for Brain;

Cognition and Behaviour;

Centre for Neuroscience;

Faculty of Science;

Radboud University;

6525AJ Nijmegen;

The Netherlands;

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原文格式 PDF
正文语种 chi
中图分类神经病学与精神病学;
关键词
sclerosis; outside; essentially;

Pharmacological interventions targeting nuclear factor-kappa B signaling in multiple sclerosis

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