Tau is the prime participant in the Alzheimer’s disease(AD) neurodegeneration:AD,the main cause of dementia in elderly people,is a multifactorial neurodegenerative disorder characterized by a long prodromal phase(starting more than two decades before clinical symptoms appear)with brain accumulation/misfolding of amyloidβ(Aβ)in insoluble amyloid plaques and of tau protein in neurofibrillary tangles.
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