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首页> 外文期刊>神经免疫与神经炎症（英文版） >Screening of genetic loci predisposing to herpes simplex virus infection on mouse chromosome 17
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Screening of genetic loci predisposing to herpes simplex virus infection on mouse chromosome 17

机译：易感染小鼠17号染色​​体的单纯疱疹病毒的遗传基因座的筛选

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摘要

Aim:The herpes simplex virus (HSV), one of the most common viruses infecting humans, is featured by a high infection rate and usually causes complex disorders dififcult to diagnose and treat. Disease progression is always combined with the speciifc interaction between organism and environment, but genetic factors play a decisive role in most pathogenic processes. Like most human disorders, individual difference has also been involved in the pathogenesis of HSV infection. The present study aimed to screen the potential gene loci that regulates human predisposition to HSV infection. Methods:With reference to previous studies, inbred mouse lines with signiifcantly distinct predisposition to HSV infection were chosen for gene loci screening. Gene sites on mouse chromosome 17 associated with susceptibility to HSV infection were then identiifed by correlation analysis and genome-wide scanning technique. Results: Genes affecting the vulnerability of mice to HSV infection were mapped to three regions on the 17th mouse chromosome, D17MIT51.1, D17MIT39.1 and the region between D17MIT180.1 and D17MIT184. Conclusion: The results suggest that the mouse genetic background plays an important role in its susceptibility to HSV-1 infection, which might be regulated by multiple predisposing quantitative trait loci.
机译：目的：单纯疱疹病毒（HSV）是人类最常见的病毒之一，具有很高的感染率，通常会导致难以诊断和治疗的复杂疾病。疾病进展总是与生物体与环境之间的特定相互作用结合在一起，但是遗传因素在大多数致病过程中起着决定性作用。像大多数人类疾病一样，个体差异也与HSV感染的发病机制有关。本研究旨在筛选潜在的基因位点，该基因位点调节人类对HSV感染的易感性。方法：参考以前的研究，选择对HSV感染有明显不同倾向的近交小鼠系进行基因座筛选。然后，通过相关分析和全基因组扫描技术，鉴定小鼠17号染色​​体上与HSV感染易感性相关的基因位点。结果：将影响小鼠对HSV感染的易感性的基因定位到第17个小鼠染色体上的三个区域D17MIT51.1，D17MIT39.1和D17MIT180.1与D17MIT184之间的区域。结论：结果表明，小鼠的遗传背景在其对HSV-1感染的易感性中起重要作用，这可能是由多个易感的数量性状基因座所调节的。

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  • 来源
    《神经免疫与神经炎症（英文版）》 |2016年第12期|-246--238|共9页
  • 作者

    Xiu-Ying Chen; Wei-Ju Tang; Xu-Zheng Zuo; Gong Wang; Hao-Xiang Wang; Peng Xie; Wen Huang;

  • 作者单位

    Depatment of Neurology, Xinqiao Hospital, the Third Military Medical University, Chongqing 400037, China;

    Depatment of Neurology, Xinqiao Hospital, the Third Military Medical University, Chongqing 400037, China;

    Depatment of Neurology, Xinqiao Hospital, the Third Military Medical University, Chongqing 400037, China;

    Depatment of Neurology, Xinqiao Hospital, the Third Military Medical University, Chongqing 400037, China;

    Depatment of Neurology, Xinqiao Hospital, the Third Military Medical University, Chongqing 400037, China;

    Depatment of Neurology, the First Afifliated Hospital, Chongqing Medical University, Chongqing 400016, China;

    Depatment of Neurology, Xinqiao Hospital, the Third Military Medical University, Chongqing 400037, China;

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