Objectives To determine the relationship of the microvessel density (MVD) and metastasis of colorectal carcinoma.Methods The MVD of the 78 colorectal carcinomas was examined by using immunohistochemisty,the correlations of MVD and metastasis of the colorectal carcinomas were analyzed. Results The mean of MVD in 32 patients with metastasis of lymph nodes was higher than in 46 patients with no metastasis of lymph nodes(28.1±8.9 and 23.5±8.2,respectively),P＜0.05.The mean of MVD in 15 patients with hepatic metastasis was higher than in 63 patients with no hepatic metastasis(33.4±9.3 and 22.4±5.8,respectively),P＜0.01.MVD did not correlate with age、sex、location of tumor、histological type (P＞0.05),except for invasive depth(P＜0.01).Conclusions MVD was positive correlation with invasion and metastasis of colorectal carcinoma.The results of this study showed that MVD plays an important role in prognosticating malignant degree of colorectal carcinoma.%目的探讨微血管密度(Microvessel density,MVD)与大肠癌转移之间的关系。方法应用免疫组织化学法,检测78例大肠癌MVD的变化，分析MVD与大肠癌转移的关系。结果 32例有淋巴转移者，其MVD平均值(28.1±8.9)高于46例无淋巴结转移者(23.5±8.2)，P＜0.05。15例有肝转移者其MVD平均值(33.4±9.3)明显高于无肝转移者(22.4±5.8)，P＜0.01。另外，MVD还与大肠癌浸润深度有关(P＜0.01)，而与大肠癌患者的年龄、性别、肿瘤部位、组织学分型无关(P＞0.05)。结论MVD与肠癌浸润、转移有明显正相关关系；MVD可作为预测大肠癌恶性程度的可靠指标之一。
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