目的 探讨美心力对充血性心力衰竭(CHF)患者的治疗效果。方法 选择CHF心功能Ⅲ～Ⅳ级住院患者60例。随机分为治疗组30例，采用美心力和硝酸甘油联用；对照组30例，单用硝酸甘油。比较治疗前后两组的临床症状、体征和心功能分级、心功能指标，并观察疗效和记录有无副作用。结果 治疗组临床总有效率83．3％，对照组总有效率76．6％(P＜0．05)。心功能测定，治疗组治疗前后比较各项指标改善均有显著性差异(P＜0．01)，对照组收缩功能改善有显著性差异(P＜0．01)，舒张功能无改善(P＞0．05)。治疗组与对照组比较，收缩功能改善无差异(P>0．05)，而舒张功能改善有显著差异(P＜0．01)。治疗组在用药过程中未见毒副作用。结论 美心力是治疗CHF患者安全有效的药物，可作为CHF综合治疗药物之一用于临床。%Objectives To evaluate the therapeutic effect of cAMP on patients with congestive heart failure(CHF).Methods 60 patients with CHF ( NYHA class Ⅲ～Ⅳ) were treated in hospital, and were divided into two groups, cAMP group(n = 30) were treated with cAMP and nitroghycerin, control group (n= 30)were treated only with nitroglycerin. Before and after the treatment, clinical symptoms, singns, cardiac functional classes and inotropic indices of both groups were investigated, the side - effects were also observed and recorded. Results Total effective rate of the cAMP group was 83.3 % and the control group was 76.6% (P＜0.05) .After the treatment,cardiac function increased temmkabaly compared with before in the cAMP group( P < 0.01 ) ,the systolic function increased remarkabaly in the control group( P＜0.01 ) ,the diastolic function were not changed( P＞0.05) .After treament, compared with the conuol group,the systolic function not increased remarkabaly(P＞0.05) ,the diastolic function increased remarkabaly in the cAMP group( P＜0.01) .There were no significant side - effects observed in the cAMP group. Conclusions cAMP was a safe, effective drug for the patients with CHF, could be one of the effective drug to treat CHF.
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