In-line X-ray phase-contrast imaging of murine liver microvasculature ex vivo

LI Beilei; XU Min; WU Weizhong; PENG Guanyun; ZHANG Xi; PENG Yifeng; SHI Hongcheng; CHEN Shaoliang

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In-line X-ray phase-contrast imaging of murine liver microvasculature ex vivo

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摘要

Imaging blood vessels is of importance for determining the vascular distribution of organs and tumors.Phase-contrast X-ray imaging can reveal the vessels in much more detail than conventional X-ray absorption method.Visualizing murine liver microvasculature ex vivo with phase-contrast X-ray imaging was performed at Shanghai Synchrotron Radiation Facility.Barium sulfate and physiological saline were used as contrast agents for the blood vessels.Blood vessels of <Φ20μm could be detected by replacing resident blood with physiological saline or barium sulfate.An entire branch of the portal vein (from the main axial portal vein to the ninth generation of branching) could be captured in a single phase-contrast image.It is demonstrated that selective angiography based on phase contrast X-ray imaging,with a physiological material of low Z elements (such as saline) being the contrast agent,is a viable imaging strategy.Further efforts will be focused on using the technique to image tumor angiogenesis.

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《核技术：英文版》 |2012年第1期|10-14|共5页
作者
LI Beilei; XU Min; WU Weizhong; PENG Guanyun; ZHANG Xi; PENG Yifeng; SHI Hongcheng; CHEN Shaoliang;
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作者单位

Department of Nuclear Medicine;

Zhongshan Hospital Affiliated to Fudan University;

Shanghai 200032;

China;

Liver Cancer Institute;

Zhongshan Hospital Affiliated to Fudan University;

Shanghai 200032;

China;

Shanghai Institute of Applied Physics;

Chinese Academy of Sciences;

Shanghai 201800;

China;

Department of Radiology;

Tumor Hospital Affiliated to Fudan University;

Shanghai 200032;

China;

Department of Radiology;

No. 10 People＇s Hospital Affiliated to Tongji University;

Shanghai 200072;

China;

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原文格式 PDF
正文语种 chi
中图分类复齿目（兔目）;
关键词
X射线成像; 相衬成像; 微血管; 体外; 小鼠; 上海同步辐射装置; 肿瘤血管生成; 生理盐水;

In-line X-ray phase-contrast imaging of murine liver microvasculature ex vivo

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